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Neurogenic Shock vs Autonomic Dysreflexia

⚡ Neurogenic Shock vs Autonomic Dysreflexia

Same patient, same spinal cord injury, opposite autonomic crises — one is a complete failure of sympathetic tone, the other is an unregulated explosion of it.

The Key Insight — Same Injury, Opposite Crises

Both conditions occur in patients with high spinal cord injuries (typically cervical or upper thoracic, at or above T6). The cord injury is the same. But the timing is different, the mechanism is opposite, and getting the two confused in an emergency could kill the patient — because the treatments are diametrically opposed.

The Single Most Important Distinguishing Fact

Blood pressure tells you which one you are dealing with:

📉 Neurogenic Shock = HYPOTENSION — sympathetic tone is lost, vessels collapse, BP falls
📈 Autonomic Dysreflexia = HYPERTENSION — sympathetic tone explodes uncontrolled, vessels constrict below the lesion, BP rockets

Both cause bradycardia — from opposite causes (one from unopposed vagal tone on a hypotensive patient; the other from the baroreflex slamming the brakes on a hypertensive patient). This shared bradycardia is the trap. The BP is what tells them apart.

📉
Neurogenic Shock
“The Cut Cables” — Sympathetic failure
ACUTE phase
TimingAcute — hours after the injury
MechanismDescending sympathetic pathways severed → loss of vasomotor tone and cardiac acceleration
BP📉 LOW — massive vasodilation, vessels dilated
HR🐢 SLOW — sympathetic cardio-acceleration cut, vagus unopposed
Skin🌡️ Warm, flushed, DRY below the lesion
TreatmentFluids → Vasopressors (Noradrenaline) + Atropine for bradycardia
📈
Autonomic Dysreflexia
“The Unregulated Explosion” — Sympathetic storm
CHRONIC phase
TimingChronic — weeks to years after injury
MechanismNoxious stimulus below lesion triggers unregulated sympathetic reflex — brain cannot inhibit it
BP📈 HIGH — severe life-threatening hypertension (e.g., 210/110)
HR🐢 SLOW — baroreflex activates vagus to try to lower BP
Skin🥵 Flushed above lesion / Pale & cool below lesion (split body)
TreatmentSit up + Find & remove trigger (usually blocked catheter) + GTN/Nifedipine
Same Injury — Opposite Autonomic Crises T6 Level SCI NEUROGENIC SHOCK Acute phase — “Cut Cables” Brain sending signals — but cut off BROKEN Vessels DILATED ↓ BP, ↓ HR Warm dry skin Heart 🐢 Bradycardic (vagus unopposed) AUTONOMIC DYSREFLEXIA Chronic phase — “Unregulated Explosion” Brain Detects ↑↑ BP Fires VAGUS ↓ Vagus (CN X) bypasses cord Cord lesion blocks inhibition SYMPATH. STORM ↑ TRIGGER e.g. blocked catheter Below: vessels CONSTRICTED 📈↑↑ BP Above: flushed sweating, headache Both cause BRADYCARDIA — but from opposite mechanisms. BP is the differentiator: ↓ = Neurogenic Shock | ↑ = Autonomic Dysreflexia
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